Pair Name	Polyphyllin I, Palbociclib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	CCNE1	hsa898
	Down-regulation	Phosphorylation	CDK2	hsa1017
	Down-regulation	Phosphorylation	CDK4	hsa1019
	Down-regulation	Phosphorylation	CDK6	hsa1021
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Phosphorylation	RB1	hsa5925
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H460	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0459
In Vivo Model	A549 cells (3×10⁶) in 0.2 mL medium were injected subcutaneously into the right flank of each nude mice.
Result	We first time demonstrated PPI can disturb CDK2 function through upregulation of p21. The PPI effect on CDK2 provides a choice for a chemotherapeutic strategy for the elimination of NSCLC. Our study highlighted the clinical significance of simultaneously blocking of CDK2 and CDK4/6 for NSCLC treatment.